Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood
Identifieur interne : 004634 ( Main/Exploration ); précédent : 004633; suivant : 004635Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood
Auteurs : Minji Byun ; Cindy S. Ma ; Arzu Akçay ; Vincent Pedergnana ; Umaimainthan Palendira ; Jinjong Myoung ; Danielle T. Avery ; Yifang Liu ; Avinash Abhyankar ; Lazaro Lorenzo ; Monika Schmidt ; Hye Kyung Lim ; Olivier Cassar ; Melanie Migaud ; Flore Rozenberg ; Nur Canpolat ; Gönül Aydo An ; Bernhard Fleckenstein ; Jacinta Bustamante ; Capucine Picard ; Antoine Gessain ; Emmanuelle Jouanguy ; Ethel Cesarman ; Martin Olivier ; Philippe Gros ; Laurent Abel ; Michael Croft ; Stuart G. Tangye ; Jean-Laurent CasanovaSource :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 2013.
Abstract
Human OX40 is necessary for robust CD4+ T cell memory and confers selective protective immunity against HHV-8 infection in endothelial cells.
Url:
DOI: 10.1084/jem.20130592
PubMed: 23897980
PubMed Central: 3754857
Affiliations:
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Ma</name><affiliation><nlm:aff id="aff2"><institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Akcay, Arzu" sort="Akcay, Arzu" uniqKey="Akcay A" first="Arzu" last="Akçay">Arzu Akçay</name><affiliation><nlm:aff id="aff4"><institution>Department of Pediatric Hematology and Oncology, Kanuni Sultan Suleyman Education and Research Hospital, 34303 Istanbul, Turkey</institution></nlm:aff></affiliation></author><author><name sortKey="Pedergnana, Vincent" sort="Pedergnana, Vincent" uniqKey="Pedergnana V" first="Vincent" last="Pedergnana">Vincent Pedergnana</name><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Palendira, Umaimainthan" sort="Palendira, Umaimainthan" uniqKey="Palendira U" first="Umaimainthan" last="Palendira">Umaimainthan Palendira</name><affiliation><nlm:aff id="aff2"><institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Myoung, Jinjong" sort="Myoung, Jinjong" uniqKey="Myoung J" first="Jinjong" last="Myoung">Jinjong Myoung</name><affiliation><nlm:aff id="aff7"><institution>Novartis Institutes for Biomedical Research, Emeryville, CA 94608</institution></nlm:aff></affiliation></author><author><name sortKey="Avery, Danielle T" sort="Avery, Danielle T" uniqKey="Avery D" first="Danielle T." last="Avery">Danielle T. Avery</name><affiliation><nlm:aff id="aff2"><institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Liu, Yifang" sort="Liu, Yifang" uniqKey="Liu Y" first="Yifang" last="Liu">Yifang Liu</name><affiliation><nlm:aff id="aff8"><institution>Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Abhyankar, Avinash" sort="Abhyankar, Avinash" uniqKey="Abhyankar A" first="Avinash" last="Abhyankar">Avinash Abhyankar</name><affiliation><nlm:aff id="aff1"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Lorenzo, Lazaro" sort="Lorenzo, Lazaro" uniqKey="Lorenzo L" first="Lazaro" last="Lorenzo">Lazaro Lorenzo</name><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Monika" sort="Schmidt, Monika" uniqKey="Schmidt M" first="Monika" last="Schmidt">Monika Schmidt</name><affiliation><nlm:aff id="aff9"><institution>Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany</institution></nlm:aff></affiliation></author><author><name sortKey="Lim, Hye Kyung" sort="Lim, Hye Kyung" uniqKey="Lim H" first="Hye Kyung" last="Lim">Hye Kyung Lim</name><affiliation><nlm:aff id="aff1"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Cassar, Olivier" sort="Cassar, Olivier" uniqKey="Cassar O" first="Olivier" last="Cassar">Olivier Cassar</name><affiliation><nlm:aff id="aff10"><institution>Epidemiology and Physiopathology of Oncogenic Viruses Unit, Institut Pasteur, 75724 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Migaud, Melanie" sort="Migaud, Melanie" uniqKey="Migaud M" first="Melanie" last="Migaud">Melanie Migaud</name><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><affiliation><nlm:aff id="aff11"><institution>EA1833, Paris Descartes University and Virology Service, Cochin Hospital, 75014 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Canpolat, Nur" sort="Canpolat, Nur" uniqKey="Canpolat N" first="Nur" last="Canpolat">Nur Canpolat</name><affiliation><nlm:aff id="aff12"><institution>Department of Pediatric Nephrology, Cerrahpasa Faculty of Medicine, Istanbul University, 34156 Istanbul, Turkey</institution></nlm:aff></affiliation></author><author><name sortKey="Aydo An, Gonul" sort="Aydo An, Gonul" uniqKey="Aydo An G" first="Gönül" last="Aydo An">Gönül Aydo An</name><affiliation><nlm:aff id="aff4"><institution>Department of Pediatric Hematology and Oncology, Kanuni Sultan Suleyman Education and Research Hospital, 34303 Istanbul, Turkey</institution></nlm:aff></affiliation></author><author><name sortKey="Fleckenstein, Bernhard" sort="Fleckenstein, Bernhard" uniqKey="Fleckenstein B" first="Bernhard" last="Fleckenstein">Bernhard Fleckenstein</name><affiliation><nlm:aff id="aff9"><institution>Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany</institution></nlm:aff></affiliation></author><author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Study Center for Primary Immunodeficiencies</institution></nlm:aff></affiliation></author><author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Study Center for Primary Immunodeficiencies</institution></nlm:aff></affiliation></author><author><name sortKey="Gessain, Antoine" sort="Gessain, Antoine" uniqKey="Gessain A" first="Antoine" last="Gessain">Antoine Gessain</name><affiliation><nlm:aff id="aff10"><institution>Epidemiology and Physiopathology of Oncogenic Viruses Unit, Institut Pasteur, 75724 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name><affiliation><nlm:aff id="aff1"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Cesarman, Ethel" sort="Cesarman, Ethel" uniqKey="Cesarman E" first="Ethel" last="Cesarman">Ethel Cesarman</name><affiliation><nlm:aff id="aff8"><institution>Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Olivier, Martin" sort="Olivier, Martin" uniqKey="Olivier M" first="Martin" last="Olivier">Martin Olivier</name><affiliation><nlm:aff wicri:cut=" and" id="aff14"><institution>Department of Microbiology and Immunology</institution></nlm:aff></affiliation></author><author><name sortKey="Gros, Philippe" sort="Gros, Philippe" uniqKey="Gros P" first="Philippe" last="Gros">Philippe Gros</name><affiliation><nlm:aff id="aff14"><institution>Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada</institution></nlm:aff></affiliation></author><author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><affiliation><nlm:aff id="aff1"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Croft, Michael" sort="Croft, Michael" uniqKey="Croft M" first="Michael" last="Croft">Michael Croft</name><affiliation><nlm:aff id="aff15"><institution>La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037</institution></nlm:aff></affiliation></author><author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. 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Ma</name><affiliation><nlm:aff id="aff2"><institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Akcay, Arzu" sort="Akcay, Arzu" uniqKey="Akcay A" first="Arzu" last="Akçay">Arzu Akçay</name><affiliation><nlm:aff id="aff4"><institution>Department of Pediatric Hematology and Oncology, Kanuni Sultan Suleyman Education and Research Hospital, 34303 Istanbul, Turkey</institution></nlm:aff></affiliation></author><author><name sortKey="Pedergnana, Vincent" sort="Pedergnana, Vincent" uniqKey="Pedergnana V" first="Vincent" last="Pedergnana">Vincent Pedergnana</name><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Palendira, Umaimainthan" sort="Palendira, Umaimainthan" uniqKey="Palendira U" first="Umaimainthan" last="Palendira">Umaimainthan Palendira</name><affiliation><nlm:aff id="aff2"><institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Myoung, Jinjong" sort="Myoung, Jinjong" uniqKey="Myoung J" first="Jinjong" last="Myoung">Jinjong Myoung</name><affiliation><nlm:aff id="aff7"><institution>Novartis Institutes for Biomedical Research, Emeryville, CA 94608</institution></nlm:aff></affiliation></author><author><name sortKey="Avery, Danielle T" sort="Avery, Danielle T" uniqKey="Avery D" first="Danielle T." last="Avery">Danielle T. Avery</name><affiliation><nlm:aff id="aff2"><institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Liu, Yifang" sort="Liu, Yifang" uniqKey="Liu Y" first="Yifang" last="Liu">Yifang Liu</name><affiliation><nlm:aff id="aff8"><institution>Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Abhyankar, Avinash" sort="Abhyankar, Avinash" uniqKey="Abhyankar A" first="Avinash" last="Abhyankar">Avinash Abhyankar</name><affiliation><nlm:aff id="aff1"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Lorenzo, Lazaro" sort="Lorenzo, Lazaro" uniqKey="Lorenzo L" first="Lazaro" last="Lorenzo">Lazaro Lorenzo</name><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Monika" sort="Schmidt, Monika" uniqKey="Schmidt M" first="Monika" last="Schmidt">Monika Schmidt</name><affiliation><nlm:aff id="aff9"><institution>Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany</institution></nlm:aff></affiliation></author><author><name sortKey="Lim, Hye Kyung" sort="Lim, Hye Kyung" uniqKey="Lim H" first="Hye Kyung" last="Lim">Hye Kyung Lim</name><affiliation><nlm:aff id="aff1"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Cassar, Olivier" sort="Cassar, Olivier" uniqKey="Cassar O" first="Olivier" last="Cassar">Olivier Cassar</name><affiliation><nlm:aff id="aff10"><institution>Epidemiology and Physiopathology of Oncogenic Viruses Unit, Institut Pasteur, 75724 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Migaud, Melanie" sort="Migaud, Melanie" uniqKey="Migaud M" first="Melanie" last="Migaud">Melanie Migaud</name><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><affiliation><nlm:aff id="aff11"><institution>EA1833, Paris Descartes University and Virology Service, Cochin Hospital, 75014 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Canpolat, Nur" sort="Canpolat, Nur" uniqKey="Canpolat N" first="Nur" last="Canpolat">Nur Canpolat</name><affiliation><nlm:aff id="aff12"><institution>Department of Pediatric Nephrology, Cerrahpasa Faculty of Medicine, Istanbul University, 34156 Istanbul, Turkey</institution></nlm:aff></affiliation></author><author><name sortKey="Aydo An, Gonul" sort="Aydo An, Gonul" uniqKey="Aydo An G" first="Gönül" last="Aydo An">Gönül Aydo An</name><affiliation><nlm:aff id="aff4"><institution>Department of Pediatric Hematology and Oncology, Kanuni Sultan Suleyman Education and Research Hospital, 34303 Istanbul, Turkey</institution></nlm:aff></affiliation></author><author><name sortKey="Fleckenstein, Bernhard" sort="Fleckenstein, Bernhard" uniqKey="Fleckenstein B" first="Bernhard" last="Fleckenstein">Bernhard Fleckenstein</name><affiliation><nlm:aff id="aff9"><institution>Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany</institution></nlm:aff></affiliation></author><author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Study Center for Primary Immunodeficiencies</institution></nlm:aff></affiliation></author><author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff13"><institution>Study Center for Primary Immunodeficiencies</institution></nlm:aff></affiliation></author><author><name sortKey="Gessain, Antoine" sort="Gessain, Antoine" uniqKey="Gessain A" first="Antoine" last="Gessain">Antoine Gessain</name><affiliation><nlm:aff id="aff10"><institution>Epidemiology and Physiopathology of Oncogenic Viruses Unit, Institut Pasteur, 75724 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name><affiliation><nlm:aff id="aff1"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Cesarman, Ethel" sort="Cesarman, Ethel" uniqKey="Cesarman E" first="Ethel" last="Cesarman">Ethel Cesarman</name><affiliation><nlm:aff id="aff8"><institution>Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Olivier, Martin" sort="Olivier, Martin" uniqKey="Olivier M" first="Martin" last="Olivier">Martin Olivier</name><affiliation><nlm:aff wicri:cut=" and" id="aff14"><institution>Department of Microbiology and Immunology</institution></nlm:aff></affiliation></author><author><name sortKey="Gros, Philippe" sort="Gros, Philippe" uniqKey="Gros P" first="Philippe" last="Gros">Philippe Gros</name><affiliation><nlm:aff id="aff14"><institution>Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada</institution></nlm:aff></affiliation></author><author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><affiliation><nlm:aff id="aff1"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation></author><author><name sortKey="Croft, Michael" sort="Croft, Michael" uniqKey="Croft M" first="Michael" last="Croft">Michael Croft</name><affiliation><nlm:aff id="aff15"><institution>La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037</institution></nlm:aff></affiliation></author><author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name><affiliation><nlm:aff id="aff2"><institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales 2010, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation><nlm:aff id="aff1"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, 75015 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Imagine Institute, Paris Descartes University, 75270 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff13"><institution>Pediatric Hematology–Immunology Unit, Necker Hospital, AP-HP, 75015 Paris, France</institution></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Experimental Medicine</title><idno type="ISSN">0022-1007</idno><idno type="eISSN">1540-9538</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Human OX40 is necessary for robust CD4<sup>+</sup> T cell memory and confers selective protective immunity against HHV-8 infection in endothelial cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abecasis, G R" uniqKey="Abecasis G">G.R. 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Ma</name><name sortKey="Migaud, Melanie" sort="Migaud, Melanie" uniqKey="Migaud M" first="Melanie" last="Migaud">Melanie Migaud</name><name sortKey="Myoung, Jinjong" sort="Myoung, Jinjong" uniqKey="Myoung J" first="Jinjong" last="Myoung">Jinjong Myoung</name><name sortKey="Olivier, Martin" sort="Olivier, Martin" uniqKey="Olivier M" first="Martin" last="Olivier">Martin Olivier</name><name sortKey="Palendira, Umaimainthan" sort="Palendira, Umaimainthan" uniqKey="Palendira U" first="Umaimainthan" last="Palendira">Umaimainthan Palendira</name><name sortKey="Pedergnana, Vincent" sort="Pedergnana, Vincent" uniqKey="Pedergnana V" first="Vincent" last="Pedergnana">Vincent Pedergnana</name><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><name sortKey="Schmidt, Monika" sort="Schmidt, Monika" uniqKey="Schmidt M" first="Monika" last="Schmidt">Monika Schmidt</name><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. 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